Table 5.

Clinical and genetic parameters assessed with the screening test Pill Protect^®.

Clinical variables	Age
	BMI
	Smoking habits
	Family history of VTE
Genetic variables	Gene: F5     -SNP: rs6025     Allele: A	Gene encoding for coagulation factor V. The resulting re6025(A) allele is known as Factor V Leiden mutation which leads to a resistance to the activated protein C and an increased risk of thrombosis (114).
	Gene: F2     -SNP: rs1799963     Allele: A	Gene encoding for prothrombin. The resulting rs199963(A) allele is known as G20210A mutation which leads to increased plasma prothrombin levels and an increased risk of thrombosis (114).
	Gene: ABO     -SNP: rs8176719     Allele: G     -SNP: rs8176750     Allele: C	Gene encoding for ABO subtype. The rs8176719(G) and rs8176750(C) alleles encodes for non-O blood groups and are associated with an increased risk of VTE through modifications of von Willebrand Factor (VWF) and factor VIII (FVIII) plasma levels (115).
	Gene: F11     -SNP: rs2289252     Allele: T	Gene encoding for coagulation factor XI. The rs2289252(T) allele is associated with increased FXI activity leading to a procoagulable state (115).
	Gene: CYP2C9     -SNP: rs1799853     Allele: T	Gene encoding for cytochrome CYP2C9 involved in the metabolism of EE. The rs1799853(T) allele could induce a decrease in the metabolism of EE, thus increasing its plasma levels and therefore the global estrogenicity (114).
	Gene: PROCR     -SNP: rs9574     Allele: G	Gene encoding for activated protein C receptor involved in the activation of the anticoagulant pathway. The rs9574(G) allele has been reported to be at increased risk of VTE compared to C allele (115).
	Gene: SUGCT     -SNP: rs4379368     Allele: T	Gene encoding for the succinate-hydroxymethylglutarate CoA-transferase. The rs4379368(T) allele has been associated with migraine susceptibility. The combination of both migraine and COC could further increase the risk of cardiovascular diseases (116).
	Gene: KNG1     -SNP: rs710446     Allele: C	Gene encoding for kininogen-1. This protein plays an important role in the coagulation process by assembling the kallikrein-kinin system. The rs710446(C) allele has been associated with shortened aPTT levels and an increased risk of VTE (117).

BMI, Body Mass Index; SNP, single nucleotide polymorphism; VTE, venous thromboembolism.