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. 2021 Dec 23;12(2):692–697. doi: 10.1039/d1ra08015f

Optimization for the formation of 3.

graphic file with name d1ra08015f-u1.jpg
Entry Variation from standard conditionsa Yieldb [%]
1 None 96
2 W/o Cu(OTf)2 No reaction
3 Cu(OTf)2 (1 mol%) 65
4 Cu(OTf)2 (5 mol%) 99
5 Cu(OTf)2 (8 mol%) 99
6 Ni(OTf)2 instead of Cu(OTf)2 61
7 Zn(OTf)2 instead of Cu(OTf)2 15
8 Sc(OTf)2 instead of Cu(OTf)2 44
9 DCE instead of DCM 91
10 0 °C 34
11 50 °C 98
12 80 °C 75
13 1 (0.60 mmol) 84
14 2 (1.5 equiv.) 99
a

Standard conditions: 1 (1.2 equiv.), 2 (0.30 mmol, 1.0 equiv.), Cu(OTf)2 (3 mol%), DCM (1.0 mL), 25 °C, 12 h.

b

Isolated yield (average of 2 independent runs). DCE = 1,2-dichloroethane, DCM = dichloromethane.