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. 2021 Nov 24;9(12):1758. doi: 10.3390/biomedicines9121758

Figure 3.

Figure 3

VitD3-tolDC reduce the activation of T lymphocytes in RRMS patients and HD. The percentage of activated CD4 + lymphocytes (CD3+CD4+HLA-DR+CD38+) (green) and CD8+ lymphocytes (CD3+CD8+HLA-DR+CD38+) (gray) in co-cultures of PBMC with mature DC (mDC), (100% VitD3-tolDC) or (50%VitD3-tolDC), in presence/absence of IFN-beta was analyzed in relapsing-remitting multiple sclerosis (RRMS) patients (A) and healthy donors (HD) (B) (n = 6 each group). Data represent the relative percentage of each lymphocyte subpopulation n relation to total percentages of CD4+ or CD8+ T cells. Error bars correspond to SEM; * p < 0.05, ** p < 0.01.