Table 1.
The zone of inhibition diameters of halicin discs at a concentration range of 128 to 16 μg/mL against S. aureus ATCC BAA-977 and E. coli ATCC 25922, while the concentration range was 256 to 16 μg/mL against A. baumannii ATCC BAA-747 and 3086 MDR isolate. Halicin was effective against all the ATCC bacterial strains at all concentrations, while it was only effective at >128 μg/mL for the MDR A. baumannii. The data show a strong correlation coefficient between the MICs and their bacterial inhibitory activity. The results represent the mean (±SD) of n = 3.
| Bacterial Strain | Halicin Concentration (μg/mL) | Zone of Inhibition (mm) Mean ± SD (n = 3) | Correlation Coefficient (R) |
|---|---|---|---|
| S. aureus ATCC BAA-977 | 16 | 17 ± 1 | 0.90 |
| 32 | 21 ± 0 | ||
| 64 | 27 ± 1 | ||
| 128 | 29 ± 1 | ||
| E. coli ATCC 25922 | 16 | 11 ± 1 | 0.98 |
| 32 | 14 ± 1 | ||
| 64 | 16 ± 1 | ||
| 128 | 20 ± 0 | ||
| A. baumannii ATCC BAA-747 | 16 | 10 ± 1 | 0.98 |
| 32 | 11 ± 1 | ||
| 64 | 14 ± 0 | ||
| 128 | 20 ± 0 | ||
| 256 | 25 ± 1 | ||
| A. baumannii MDR 3086 | 16 | 0 | 0.93 |
| 32 | 0 | ||
| 4 | 11 ± 1 | ||
| 128 | 14 ± 1 | ||
| 256 | 22 ± 1 |