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. 2021 Dec 17;9(12):1931. doi: 10.3390/biomedicines9121931

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Discrimination among PC patients with or without fibrosis-like symptoms according to plasma levels of IFN-β. (A) The contingency graph that describes that lung fibrosis-like changes are more frequent in severe (red bar, 82.6%) than moderate (green bar, 72.4%) COVID-19 patients. Fisher’s exact test was used to determine the possible association between COVID-19 and lung fibrosis events (p < 0.0001). (B) Fraction of total was analyzed according to the levels of IFN-β based on a cut-off (194.3 pg/mL) obtained by receiver operating curve (ROC) analysis; in this latter analysis, the Chi-square test for trend (p = 0.0154) was applied.