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. 2021 Dec 15;10(12):2001. doi: 10.3390/antiox10122001

Figure 7.

Figure 7

Effect of diet, quercetin and A. muciniphila supplementation on the expression of BA and lipid metabolism genes in the liver of juvenile NAFLD rats. (A) Liver mRNA expression of main BA synthesis genes (Cyp7a1 and Cyp8b1), and of major basolateral BA uptake (Ntcp) and canalicular bile efflux (Bsep, Mrp2 and Mdr2) transporters. (B) Expression of the BA-CoA ligase (Fatp5), the BA-CoA:amino acid N-acyltransferase (Baat), and of the BA-related nuclear receptors Fxr, Pxr, Lxrα, and Shp. Expression of mRNA is normalized to the mean values of C rats. Data represent mean ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001, vs. C; # p < 0.05, ## p < 0.01, ### p < 0.001, vs. C[HFD] by one-way ANOVA followed by Tukey’s multiple comparison test.