Figure 3.

Correlation between SAA1, IP-10, and IL-6 levels and total/ lung pathology score at the endpoint. (a) SAA1, (b) IP-10, and (c) IL-6 levels (x-axis) were measured by UCP-LFA in serum from MTB Erdman infected rhesus macaques (n = 75, see Figure 1). Tuberculosis pathology (PA; y-axis) scoring methods are described in Materials and Methods (2.2), and PA is expressed as arbitrary units (AU). R² is the square of the Spearman correlation coefficient. (d) Values above the cutoff per biomarker (described in Table 1b) were considered positive. 3BM (x-axis) was generated using the sum of all positive tests results from the individual markers. (a–d) SAA1, IP-10, IL-6, and 3BM showed a good correlation with total- and lung pathology scores at the endpoint.