Table 4.

SOCs inhibitors used as research tool.

Compound	Mode of Action	IC50	Side Effects	References
Orai1 Inhibitor
YM-58483 (BTP2 or Pyr2)	-	10–590 nM	Inhibits TRPC3 and -C6 (IC50: 0.3 µM) Activates TRPM4 channels (EC50: 8 nM) Inhibit Orai2 and Orai3 at 10 µM	[214,215,216,217,218,219]
GSK7975A and GSK-5503A	Potentially allosteric effect on the selectivity filter of Orai	4 µM	Orai2 and Orai3 at 10 µM, L-type Ca2+ (IC50: 8 µM), and TRPV6 channels	[219,220]
Synta-66	Binds TM1 and TM3 helices and the extracellular loop segments	26 nM-3 µM	Potentiate Orai2 at 10 µM	[219,221,222,223,224]
JPIII	-	244 nM	-	[225]
Gd3+ or La3+	Binds extracellular loop of Orai1	200 nM	Inhibit Orai2/3	[219,226]
AnCoA4	Binds the C-terminus of Orai1	880 nM	-	[227]
5J-4	-	10 µM	-	[228]
STIM1 Inhibitor
ML-9	Inhibit STIM1 puncta formation	10 µM	Inhibit Myosin light chain kinase	[229]
TRPC3 Inhibitor
Pyr3	Direct binding	0.7 μM	-	[230]
Pyr10	-	0.72 µM	-	[218]
TRPC4 Inhibitor
ML-204	-	1–3 μM	Inhibit TRPC5 and weakly TRPC6	[231]
HC-070	Direct binding	9.3 nM	Inhibit TRPC4 (IC50:46 nM) and TRPC3 (IC50: 1 µM)	[232,233]
HC-608 (Pico145)	-	0.35 nM	Inhibit TRPC5 (IC50: 1.3 nM), TRPC1-4 complex (IC50: 0.03 nM) and TRPC1-5 complex (IC50: 0.2 nM)	[234]
TRPC5 Inhibitor
AC1903	-	13.6 μM	Inhibit TRPC4 (IC50 > 100 µM)	[235]
GFB-8438	Direct binding	0.18 µM	Inhibit TRPC4 (IC50: 0.29 µM)	[236,237]
TRPC6 Inhibitor
SAR7334	-	9.5 nM	Inhibit TRPC3 (IC50: 282 nM) and TRPC7 (IC50: 226 nM)	[238]
SKF-96365	-	10 µM	-	[239]
GSK2833503	-	3 nM	Inhibit TRPC3 (IC50: 21 nM)	[240,241]
BI 749327	-	19 nM	-	[242]
SH045	-	7.9 nM	Inhibit TRPC3 (IC50: 282 nM) and TRPC7 (IC50: 226 nM)	[243]
AM-1473	Direct binding	0.22 nM	-	[244]

Inhibitors are classified according to their smallest IC50. EC50, half maximal effective concentration; IC50, half maximal inhibitory concentration; -, no data available.