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. 2021 Dec 15;10(12):1328. doi: 10.3390/biology10121328

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Fenofibrate eye drop had no toxic effects on cornea or retinal structure and function in mice. (A) Representative H&E images of the vehicle control group and the 0.1% fenofibrate (FF) group. No cornea or retina structural changes were observed. Scale bar: 100 μm. (B) Representative OCT images of the vehicle group and 0.1% FF group. (C) Representative images showing perfectly clear cornea without lesion after the eye drop administration. (D) Quantitative measures of central corneal and total retinal thickness using OCT. Data were expressed as mean ± SEM, n = 12 eyes in each group, analyzed by an unpaired Student’s t test. (E) The measurement of intraocular pressure (IOP) after the treatment with the eye drops. Data were expressed as mean ± SEM, analyzed by two-way ANOVA.