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. 2021 Dec 7;9(12):1850. doi: 10.3390/biomedicines9121850

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The number of miRNA binding sites (BS) generally increases with the length of the circRNA. (A) Pearson correlation analysis between circRNA length and the maximum number of BS for a single miRNA in the dataset retrieved from CircInteractome. (B) Ratio between the maximum number of miRNA BS for a single miRNA and the circRNA length for the circRNAs with more than 20 miRNA BS detected in leukocytes and EVs. CircRNAs with a ratio higher than 0.01 but smaller than 0.05 are highlighted in orange.