Table 1.

Aortic diameter for male and female mice at proximal and distal region at different timepoints

	Proximal		Distal
	Male	Female	Male	Female
Month 3
D, mm
WT	1.54 ± 0.13	1.38 ± 0.04	1.53 ± 0.07	1.41 ± 0.08
Het	1.51 ± 0.11	1.50 ± 0.05	1.65 ± 0.23	1.59 ± 0.04
P value	>0.99	0.99	>0.99	0.99
%Change	−5.048	7.77	6.88	10.85
Month 6
D, mm
WT	1.50 ± 0.16	1.43 ± 0.04	1.52 ± 0.11	1.45 ± 0.03
Het	1.62 ± 0.15	1.56 ± 0.14	1.83 ± 0.10	1.59 ± 0.11
P value	0.99	0.99	0.68	0.99
%Change	11.89	9.42	20.89	15.55
Month 9
D, mm
WT	1.67 ± 0.17	1.45 ± 0.24	1.64 ± 0.14	1.51 ± 0.07
Het	2.06 ± 0.30	1.63 ± 0.06	2.20 ± 0.29	1.80 ± 0.13
P value	0.042	0.94	0.03	0.81
%Change	23.50	12.38	31.45	35.33
Month 12
D, mm
WT	1.58 ± 0.12	1.48 ± 0.07	1.64 ± 0.12	1.52 ± 0.11
Het	2.11 ± 0.46	1.75 ± 0.08	2.32 ± 0.69	1.99 ± 0.30
P value	0.0007	0.46	0.001	0.11
%Change	26.28	16.51	35.33	31.29

Diameter values are means ± SE. Percentage change of aortic diameter calculated as [(D_Het − D_WT)/D_WT]·100, where D is diameter, WT is wild type, and Het is Fbn1^C1041G/+. With three-way ANOVA (n = 5 mice/study group), P value calculated between genotypes, with P < 0.05 considered significant.