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Study protocol. All participants completed an isoproterenol (Iso) dose-response test (1, 3, 6, and 12 ng/100 g/min). Following a washout period, a subset of participants received a loading dose of NG-monomethyl-l-arginine (l-NMMA) or ketorolac, followed by a continuous maintenance dose. Iso infusions were then repeated. After final washout period, a loading dose of the second inhibitor (ketorolac or l-NMMA) was administered and Iso infusions were repeated a final time.
