Figure 4.

Contribution of cyclooxygenase (COX) to the forearm vascular response to β-adrenergic receptor stimulation. Data are reported from a subset of participants (A: normal weight, n = 8, 3 males/5 females; B: obese, n = 5, 3 males/2 females). Both groups (normal weight, obese) exhibited an increase in forearm vascular conductance during Iso infusion (main effect of Iso, P < 0.001). Coinfusion of ketorolac (COX blockade) elicited an increase in forearm vascular conductance in normal weight (main effect of ketorolac, P = 0.009) but not adults with obesity (P = 0.120). Solid black lines = group average control. Dashed black lines = group average ketorolac. Solid gray lines = individual data control. Dashed gray lines = individual data ketorolac. Two-way repeated-measures analysis of variance. *P < 0.05 control vs. ketorolac within dose. Iso, isoproterenol.