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. 2021 Nov 5;322(1):H25–H35. doi: 10.1152/ajpheart.00449.2021

Figure 5.

Figure 5.

Contribution of NOS and COX to the forearm vascular response to β-adrenergic receptor stimulation. Data are reported from 36 (17 males/19 females) normal weight (A) and 21 (7 males/14 females) participants with obesity (B). Both groups (normal weight, obese) exhibited an increase in forearm vascular conductance during Iso infusion (main effect of Iso, P < 0.001). Double blockade [NG-monomethyl-l-arginine (l-NMMA) + ketorolac] did not significantly alter Iso-mediated changes in forearm vascular conductance in normal weight (interaction of Iso and blockade, P = 0.670) or adults with obesity (P = 0.399). Solid black lines = group average control. Dashed black lines = group average double blockade. Solid gray lines = individual data control. Dashed gray lines = individual data double blockade. Two-way repeated-measures analysis of variance. COX, cyclooxygenase; Iso, isoproterenol; NOS, nitric oxide synthase.