Table 3.

Contribution of COX to the hemodynamic response to Iso

	1 ng/100 g/min	3 ng/100 g/min	6 ng/100 g/min	12 ng/100 g/min	Main Effect of Iso	Main Effect of Ketorolac	Interaction
Brachial artery diameter, cm
Normal weight
Control	0.01 ± 0.02	0.01 ± 0.02	0.01 ± 0.01	0.01 ± 0.01	0.062	0.258
Ketorolac	0.00 ± 0.01	0.01 ± 0.01	0.02 ± 0.02	0.03 ± 0.02
Obese
Control	0.01 ± 0.01	0.01 ± 0.01	0.02 ± 0.01	0.03 ± 0.02	<0.001	0.962
Ketorolac	0.01 ± 0.02	0.02 ± 0.01	0.02 ± 0.01	0.03 ± 0.02
Forearm blood flow, mL/min/100 g
Normal weight
Control	1.6 ± 2.1	4.5 ± 3.0	8.4 ± 6.9	11.0 ± 6.2	<0.001	0.015	0.003
Ketorolac	3.2 ± 3.6	9.8 ± 6.9*	15.5 ± 12.9*	20.9 ± 13.3*
Obese
Control	4.0 ± 1.9	6.4 ± 2.2	9.6 ± 7.0	13.5 ± 5.4	<0.001	0.079
Ketorolac	4.5 ± 3.5	8.5 ± 2.1	12.0 ± 2.1	18.1 ± 7.7
Mean arterial blood pressure, mmHg
Normal weight
Control	1 ± 8	2 ± 8	0 ± 8	-1 ± 8	0.005	0.280
Ketorolac	−1 ± 1	−2 ± 2	−3 ± 2	−3 ± 2
Obese
Control	−1 ± 1	−2 ± 1	−1 ± 5	−3 ± 5	0.440	0.400
Ketorolac	−5 ± 6	−5 ± 6	−6 ± 10	−6 ± 10
Heart rate, beats/min
Normal weight
Control	−3 ± 15	−4 ± 13	−3 ± 15	−3 ± 15	0.224	0.530
Ketorolac	−2 ± 8	0 ± 2	0 ± 5	3 ± 7
Obese
Control	−4 ± 3	−4 ± 2	−4 ± 3	−3 ± 3	0.855	0.801
Ketorolac	−3 ± 6	−4 ± 4	−4 ± 12	−7 ± 6

Values are changes from baseline and are means ± SD from a subset of participants: normal weight (n = 8; 3 males/5 females) and obese (n = 5; 3 males/2 females). Two-way repeated-measures ANOVA. From the initial model that included the isoproterenol (Iso)-by-ketorolac interaction effect, no significant interaction was detected (P > 0.05). *P < 0.05 vs. control. COX, cyclooxygenase.