Table 4.
Contribution of NOS and COX to the hemodynamic response to Iso
| 1 ng/100 g/min | 3 ng/100 g/min | 6 ng/100 g/min | 12 ng/100 g/min | Main Effect of Iso | Main Effect of DB | |
|---|---|---|---|---|---|---|
| Brachial artery diameter, cm | ||||||
| Normal weight | ||||||
| Control | 0.01 ± 0.01 | 0.01 ± 0.01 | 0.01 ± 0.01 | 0.01 ± 0.01 | <0.001 | 0.450 |
| DB | 0.01 ± 0.02 | 0.01 ± 0.02 | 0.01 ± 0.02 | 0.02 ± 0.02 | ||
| Obese | ||||||
| Control | 0.01 ± 0.01 | 0.01 ± 0.01 | 0.02 ± 0.02 | 0.02 ± 0.02 | <0.001 | 0.050 |
| DB | 0.00 ± 0.01 | 0.00 ± 0.01 | 0.01 ± 0.01 | 0.01 ± 0.01 | ||
| Forearm blood flow, mL/min/100 g | ||||||
| Normal weight | ||||||
| Control | 2.0 ± 2.4 | 5.0 ± 3.3 | 8.5 ± 4.5 | 12.1 ± 6.5 | <0.001 | 0.133 |
| DB | 1.3 ± 2.0 | 4.3 ± 3.1 | 7.5 ± 5.1 | 11.8 ± 6.7 | ||
| Obese | ||||||
| Control | 3.4 ± 2.1 | 7.5 ± 3.9 | 11.9 ± 6.2 | 15.4 ± 6.0 | <0.001 | 0.139 |
| DB | 1.5 ± 3.5 | 5.4 ± 4.9 | 9.3 ± 6.3 | 15.2 ± 8.2 | ||
| Mean arterial blood pressure, mmHg | ||||||
| Normal weight | ||||||
| Control | 0 ± 2 | −1 ± 3 | −1 ± 4 | −1 ± 5 | 0.422 | 0.336 |
| DB | 0 ± 3 | −1 ± 4 | 0 ± 4 | 1 ± 4 | ||
| Obese | ||||||
| Control | −1 ± 3 | −1 ± 2 | −1 ± 3 | −1 ± 5 | 0.756 | 0.900 |
| DB | −1 ± 3 | −2 ± 3 | −1 ± 4 | −1 ± 4 | ||
| Heart rate, beats/min | ||||||
| Normal weight | ||||||
| Control | −2 ± 12 | −3 ± 11 | −2 ± 11 | 0 ± 12 | 0.855 | 0.649 |
| DB | −1 ± 7 | 0 ± 8 | 1 ± 11 | −2 ± 17 | ||
| Obese | ||||||
| Control | −2 ± 5 | 0 ± 6 | 1 ± 6 | 1 ± 6 | 0.035 | 0.828 |
| DB | 0 ± 6 | −2 ± 5 | 0 ± 5 | 1 ± 4 |
Values are changes from baseline and are means ± SD from 36 (17 males/19 females) normal weight and 21 (7 males/14 females) participants with obesity. Two-way repeated-measures ANOVA. From the initial model that included the isoproterenol (iso)-by-double blockade (DB) interaction effect, no significant interaction was detected (P > 0.05). COX, cyclooxygenase; NOS, nitric oxide synthase.