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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Autophagy activation route and lysosome-nuclei communication. The mTORC1 complex, attached to the lysosomal membrane, controls the activation of TFEB, which is translocated to the nucleus to activate the genes that regulate the autophagic process.