Table 2.
KEGG analysis of coordinately expressed transcripts in Lrp2 knockout and Dab2 knockout cells
| Term | Count | P Value | Genes |
|---|---|---|---|
| Sphingolipid signaling pathway | 11 | 0.00087 | PPP2CA, NRAS, CERS6, SPTLC2, PPP2R3C, SMPD1, GNAI3, AKT1, PPP2R5C, S1PR2, SGPP1 |
| Sphingolipid metabolism | 7 | 0.00102 | ARSA, CERS6, SPTLC2, SMPD1, B4GALT6, GLA, SGPP1 |
| Lysosome | 10 | 0.00291 | MFSD8, ARSA, NPC1, ATP6AP1, SORT1, SMPD1, NAGA, ACP5, AP4B1, GLA |
| Estrogen signaling pathway | 8 | 0.00993 | NRAS, HSP90AA1, CREB3L3, MMP2, GNAI3, AKT1, SOS2, HBEGF |
| Axon guidance | 9 | 0.01354 | EFNA1, SEMA5A, ITGB1, NRP1, NRAS, EPHA6, SEMA3C, CFL2, GNAI3 |
| Mineral absorption | 5 | 0.01459 | SLC6A19, HMOX1, MT2, ATP1A1, SLC5A1 |
| TNF signaling pathway | 8 | 0.01712 | NFKBIA, CXCL10, EDN1, CASP8, CREB3L3, CCL20, AKT1, TNFAIP3 |
| Prostate cancer | 7 | 0.02040 | NFKBIA, NRAS, HSP90AA1, CREB3L3, AKT1, IGF1, SOS2 |
| Ascorbate and aldarate metabolism | 4 | 0.02732 | ALDH3A2, MIOX, UGDH, RGN |
| Arginine and proline metabolism | 5 | 0.03116 | ALDH3A2, GAMT, ARG2, P4HA2, L3HYPDH |
| Metabolic pathways | 42 | 0.03291 | CDA, DDC, HAAO, MSMO1, PYGL, PIGV, TM7SF2, EXTL2, MTHFD1L, SPTLC2, MAN1A2, SMPD1, DSE, PHGDH, HMGCS2, CEPT1, MGAT2, PTGDS, NDUFV1, GAMT, GALNT7, FDPS, ARG2, PLA2G12B, CERS6, HSD3B2, HMGCS1, ATP6AP1, AGXT2, URAD, ACSL5, AMPD2, COQ6, ALDH3A2, UGDH, SQLE, UCK2, P4HA2, DPYD, RGN, B4GALT6, HPD |
| Biosynthesis of antibiotics | 11 | 0.03678 | ALDH3A2, FDPS, SQLE, ARG2, HMGCS1, RGN, PHGDH, AMPD2, MSMO1, HMGCS2, TM7SF2 |
| Phosphatidylinositol 3-kinase-Akt signaling pathway | 15 | 0.04826 | ITGB1, HSP90AA1, COL27A1, ITGB4, LAMA3, IGF1, PPP2R5C, EFNA1, PPP2CA, NRAS, CREB3L3, PPP2R3C, AKT1, SGK1, SOS2 |
Transcripts that were coordinately upregulated or downregulated by 30% (0.75–1.3 times control) were collected from Supplemental Table S2, and the merged list was subjected to Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. Pathways with a P value of <0.05 are shown along with the number and names of the genes represented. Dab2, Dab2; Lrp2, megalin.