Table 3.
Membrane trafficking genes whose expression is altered in Lrp2 KO cells
| Lrp2 KO/Control | Gene | Protein |
|---|---|---|
| 0.27 | CLIP2 | CAP-Gly domain containing linker protein 2 |
| 0.49 | HIP1 | Huntingtin interacting protein 1 |
| 0.50 | COPS9 | COP9 signalosome subunit 9 |
| 0.54 | SNAP91 | Clathrin coat-associated protein AP180 |
| 0.55 | STXBP5 | Syntaxin-binding protein 5 |
| 0.57 | RAB32 | RAB32, member of the RAS oncogene family |
| 0.57 | RABGEF1 | RAB guanine nucleotide exchange factor 1 |
| 0.58 | SORL1 | Sortilin-related receptor 1 |
| 0.59 | STX7 | Syntaxin 7 |
| 0.59 | IGF2R | Insulin-like growth factor 2 receptor |
| 0.60 | IPCEF1 | Interaction protein for cytohesin exchange factors 1 |
| 0.62 | VTA1 | Vesicle trafficking 1 |
| 0.62 | SMAP1 | Small ArfGAP 1 |
| 0.62 | HACE1 | HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 |
| 0.62 | RAB23 | RAB23, member of the RAS oncogene family |
| 0.64 | MYO7A | Myosin VIIA |
| 0.65 | SNX3 | Sorting nexin 3 |
| 0.66 | MICAL1 | Microtubule-associated monooxygenase, calponin and LIM |
| 0.66 | ATG5 | Autophagy related 5 |
| 0.67 | SNX14 | Sorting nexin 14 |
| 1.52 | SNX10 | Sorting nexin 10 |
| 1.60 | CLINT1 | Clathrin interactor 1 |
| 1.62 | ARAP3 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 |
| 1.63 | SH3KBP1 | SH3 domain containing kinase binding protein 1 |
| 1.97 | PIK3R1 | Phosphoinositide 3-kinase regulatory subunit 1 |
| 2.30 | VAMP8 | Vesicle-associated membrane protein 8 |
| 5.63 | SYNPR | Synaptopodin 2 |
Genes that encode proteins with known functions in membrane traffic identified in the list of transcripts that are selectively downregulated or upregulated in megalin (Lrp2) knockout (KO) cells are listed, along with the ratio of expression relative to control cells.