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. 2021 Dec 16;9(12):1929. doi: 10.3390/biomedicines9121929

Figure 2.

Figure 2

Linear correlation between change in plasma level of sPD-1 and change in tumor size. Relative changes in sPD-1 were calculated as the concentration from the baseline (pre-ICI treatment) to after two and four cycles and two to four ICI treatment cycles. Then, we evaluated its potential association with the change in tumor size from the baseline to after 4 cycles. The change in sPD-1 concentration from pre-ICI to after both two and four cycles was not significantly correlated with the percentage change in tumor size (r = 0.0386, p = 0.6409, (A); r = 0.0022, p = 0.9125, (B), respectively). The changes in sPD-1 concentration from after 2 cycles to after four cycles were positively correlated with the percentage change in tumor size with statistical significance (r = 0.4881, p = 0.024; (C)). * Statistically significant.