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. 2021 Dec 10;9(12):1877. doi: 10.3390/biomedicines9121877

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Signaling networks in different cellular compartments. (A) A heatmap represented the numbers of interacting protein pairs from each pair of clusters. Our systematic analysis revealed that the cluster pairs C/E, D/E, and C/D are over-represented. The proteins of these clusters are likely to represent major signaling partners in the response of VCaP prostate cancer cells to androgen, as may be exemplified by the well-known interaction between AR (cluster C) and SP1 (cluster D). (B) Systematic enumeration and visualization of the signaling proteins that connect cluster C to cluster E via cluster D in the context of their cellular compartments.