Table 4.

Multivariate Cox regression analysis, regarding MM patients overall and progression-free survival.

	Covariate	HR 1	95% CI 2	p Value 3	BCa 4 Bootstrap 5 95% CI 2	Bootstrap 5 p Value 3
Overall survival (OS)	i-tRF-ProTGG status
	Positive	1.00
	Negative	4.06	1.28–12.82	0.0 17	0.98–46.70	0.011
	R-ISS 6 (ordinal)	3.39	1.28–8.96	0.0 14	0.93–38.24	0.024
	i-tRF-GluCTC status
	Positive	1.00
	Negative	5.87	1.75–19.63	0.0 04	1.02–5.58 × 105	0.001
	R-ISS 6 (ordinal)	3.98	1.50–10.57	0.006	0.58 –7.39 × 105	0.010
	i-tRF-HisGTG status
	Positive	1.00
	Negative	6.49	1.94–21.74	0.0 02	0.97–7.32 × 105	0.001
	R-ISS 6 (ordinal)	3.77	1.44–9.91	0.0 07	0.87–4.42 × 105	0.008
Progression-free survival (PFS)	i-tRF-GlyGCC status
	Positive	1.00
	Negative	3.06	1.33–7.00	0.008	1.12–12.63	0.0 07
	ISS 7 (ordinal)	2.22	1.25–3.95	0.0 07	1.20–7.71	0.008
	3′-tRF-LeuAAG/TAG status
	Positive	1.00
	Negative	2.94	1.32–6.55	0.008	1.28–8.76	0.005
	ISS 7 (ordinal)	2.16	1.22–3.80	0.008	1.21–6.37	0.008

¹ Hazard ratio; ² Confidence interval; ³ Italics indicate a significant p value; ⁴ Bias-corrected and accelerated; ⁵ Based on 1000 bootstrap samples; ⁶ Revised International Staging System; ⁷ International Staging System.