Table 2.

Summaryof differences between 1st and 2nd generation acellular bACLs.

	1st Generation of Acellular bACLs	2nd Generation of Acellular bACLs
Matrix	Bovine Type I collagen hydrogel (can easily be replaced by commercially available recombinant human Type I hydrogels)	idem
Anchorage	Sterile bone plugs	Endobutton (cortical button)
	(limited availability and potential regulatory issues)
Protection of the graft during implantation	None	Dialysis membrane (efficiency tested by orthopedic surgeons)
Advantages	Surgical procedure similar to standard BPTB procedure	All items used are commercially available and approved by the FDA