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High glucose concentrations modify the traffic of Rab 5, Rab 7, Lamp-1, and cathepsin D, inducing a delay in the Mtb–MHC-II complexes formation. An intracellular decrease of the co-stimulatory molecules CD86 and MHC class II molecules is observed, affecting the antigenic presentation. The role of hyperglycemia on MARCH 1-mediated MHC-II protein degradation deserves further exploration. (www.biorender.com).
