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Effect of disrupting the actin cytoskeleton on NCC activity. The mDCT15 cells treated with latrunculin B (500 nM) or cytochalasin D (1 μM) for 30 min resulted in a decrease in NCC activity compared with the cells treated with the vehicle alone (control). Thiazide-sensitive 22Na+ uptake was calculated as the difference between the uptakes with and without thiazide. Four independent experiments were performed, N = 4. * represents p < 0.05.
