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. 2021 Dec 14;60(1):4. doi: 10.3892/ijo.2021.5294

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Copyright: © Bolatkan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Bioinformatics analysis of METTL6 expression in HCC samples using GEPIA. (A) METTL6 mRNA expression levels in TCGA_LIHC tumor tissues (n=369) and paired TCGA non-tumor tissues (n=50) using GEPIA. (B) METTL6 mRNA expression in different stages of HCC (F value=4.75; Pr [>F]=0.00295). (C) Overall survival rate and (D) disease-free survival rate in patients with HCC with high and low METTL6 mRNA levels. The group cut-off value is based on the median. (E) METTL6 copy number alterations (CNAs) and METTL6 mRNA levels (P<1.0e-04, ANOVA test). All data are presented as means±standard deviation. ^*P<0.05. METTL6, methyltransferase-like 6; GEPIA, Gene Expression Profiling Interactive Analysis; HCC, hepatocellular carcinoma; TCGA, The Cancer Genome Atlas.