. 2021 Dec 19;10(12):2014. doi: 10.3390/antiox10122014

Table 3.

Anti-photoaging activity of the flavanones.

Flavanones	Model/UV Radiation	Activities	Ref.
Hesperetin	HDFs/UVA	Decreases ROS generation; reduces collagen depletion and MMP-1 activity; positively regulates Nrf2 activity and its genes NQO-1 and GST	[82]
Hesperetin	BALB/c mice/UVA	Decreases collagen loss, MMP-1 activity, and 8-OhdG; increases nuclear Nrf2 levels and its NQO-1 and GST target proteins	[82]
Hesperidin	HaCaT cells/UVA	Increases SOD activity and total antioxidative capacity levels; reduces MDA content; decreases IL-1β, IL-6, and TNF-α mRNA levels and proteins expression	[83]
Hesperidin	Hairless mice/UVB	Decreases collagen fiber loss, wrinkle formation, and TEWL; suppresses MMP-9 activity and mRNA levels, TNF-α and IL-8 production, and ERK and MEK phosphorylation	[84]
Naringenin	HaCaT cells/UVB	Suppresses MMP-1 expression, AP-1 activity, FRA1 expression and phosphorylation, p90RSK phosphorylation, and ERK2 activity	[85]
	Hairless mice/UVB	Suppresses TEWL, wrinkle formation, and MMP-13 expression	[85]
	Hairless mice/UVB	Inhibits the IL-1β, IL-10, IL-6, and TNF-α production; suppresses lipid hydroperoxides and superoxide anion production; preserves GSH levels and CAT activity, Nrf2 mRNA expression, glutathione reductase, and GPx	[86]