. 2021 Dec 19;10(12):2014. doi: 10.3390/antiox10122014

Table 6.

Beneficial properties of flavones in different psoriasis models.

Flavones	Model/Psoriasis Inducer	Activities	Ref.
Luteolin	NHEKs and HaCaT cells	Inhibits mRNA expression of IL-8 and IL-6; reduces mRNA expression of NFKB1 and RELA and HaCaT cell proliferation	[120]
	HaCaT cells	Inhibits transcriptional expression of HSP90β and HSP90α; decreases exosomes amount	[121]
	BALB/c mice/ imiquimod	Reduces psoriatic area, PASI, histological damage, and HSP90β and HSP90α expression; decreases the proportion of Th17/Treg cells and Th1/Th2	[121]
	Raw264.7 macrophages	Decreases both mRNA and protein levels of TNF-α, IL-1β, IL-6, IL-23, and IL-17A; inhibits NF-κB p65 and COX-2 expression; suppresses iNOS and NO	[39]
	BALB/c mice/ imiquimod	Reduces PASI, infiltration of macrophage, T cells, and neutrophil, and IL-1β, IL-17A, IL-23, and IL-6 expression	[39]
Luteolin-7-glucoside	HEKn	Modifies cell cycle, energy, fatty acid, and redox metabolism; increases KRT10 expression and cortisol levels; decreases PGE₂ level	[122]
Luteolin-7-glucoside	C57BL/6 mice/imiquimod	Reduces skin psoriasis-like lesions, Ki67 and p63; increases KRT10, TGase-1, and Loricrin; modulates expression of STAT3	[122]
Baicalein	HaCaT cells	Inhibits cell growth; causes growth arrest in G₀/G₁phase; induces morphological differentiation Ca²⁺ dependent; increases KRT10 and KRT1 expression and ERK phosphorylation; activates TRPV4	[123]
Baicalin	BALB/c and ICR mice/DNFB	Reduces psoriatic symptoms, edema, and inflammatory cell infiltration; increases orthokeratosis	[124]
Baicalin	BALB/c mice/imiquimod	Reduces psoriatic symptoms, PASI, histological damage, expression of TNF-α, IL-23, IL-22, and IL-17A, and γδT cells infiltration	[116]
Chrysin	NHEKs	Attenuates phosphorylation of JNK, ERK, and p38 kinase; decreases p-STAT3 and p-JAK2; suppresses CCL20 and AMPs expression	[35]
Chrysin	BALB/c mice/imiquimod	Reduces psoriatic symptoms, PASI, histological damage, TEWL, erythema, blood flow, and thickness; increases the content of surface skin hydration	[35]
Tangeretin	HaCaT cells	Inhibits the nuclear translocation of NF-κB p65 and HIF-1α	[125]
Tangeretin	BALB/c mice/PMA-induced ear inflammation	Reduces psoriatic symptoms, histological damage, PMA-induced hyperplasia; down-regulates the production of IL-1β, IL-6, IL-4, TNF-α, IFN-γ, PGE₂, COX-2, MIP-2, MCP-1, KC, TRX, nNOS, iNOS, eNOS, MMP-9, MMP-2, TLR4, VEGF, p-Akt, p-p38, p-JNK, p-ERK1/2, NF-κB p65, NF-κB p50, IκBα, IKK-γ, and HIF-1α; suppresses MDA, and NO expression; increases SOD-2, HO-1, and CAT expression	[125]