Table 1.

Relevant data on the synergic uses of different substances with lysozyme, in order to enhance the susceptibility of Gram-negative bacteria.

Combined Use with	Application/Claimed Use	Antibiotic Activity Evaluated Against/On	Refs.
Cinnamaldehyde	Storage of olive flounder (Paralichthys olivaceus) fillets/lowered total viable count	S. putrefaciens and P. fluorescens	[177]
Acidic electrolyzed oxidizing water	To prolong the shelf life of carp fillets from a microbiological point of view	Total viable count, Enterobacteriaceae count, and anaerobic mesophilic count	[178]
Heat treatment and dilution with hydrogen peroxide associated with packaging in a controlled atmosphere	To extend the shelf life of pork meat by more than 20%, compared with the control sample without lysozyme	Aerobic plate count, Enterobacteriaceae, Pseudomonas spp., and lactic acid bacteria	[179]
High hydrostatic pressure	Not significant enough to differentiate lethality of lysozyme without additives in cheeses made from raw milk	B. cereus	[180]
Disodium ethylenediaminetetraacetate salt	Buffalo meat in refrigerated conditions	Total viable mesophilic count, total viable psychrotrophic count, lactic acid bacteria, Pseudomonas spp., and B. thermosphacta	[181]
Chitooligosaccharides	The microbiological quality of minced meat stored in refrigerated conditions was improved	Escherichia coli, Pseudomonas fluorescens, Bacillus cereus, and Staphylococcus aureus	[183]
Ethylenediaminetetraacetic acid disodium salt	To reduce the growth of Y. enterocolitica in orange beverages	Y. enterocolitica	[188]
Layer-by-layer chitosan-organic rectorite composites and negative charged sodium alginate.	The sensory analysis and physicochemical analysis applied to assess the effects of layer-by-layer film coating confirmed a higher score for the packaged pork (4 °C for 21 days)	E. coli and S. aureus	[184]
EDTA in anti-microbial starch-based active food packaging films	Cooked rice with pulses/effective to inhibit the growth of spoilage microorganisms	Contaminated from the open environmental sources (mainly Gram-negative cocci)	[185]
EDTA	A different lysozyme activity against the tested microorganisms was observed, increasing the ratio of lysozyme/EDTA from 11.14:8.14 mg/mL to 11.14:14.14 mg/mL.	Micrococcus lysodeikticus and Escherichia coli	[182]
Enterocin AS-48	Synergy confirmed in liquid whole eggs, egg whites, and egg yolks, at 4 °C and 28 °C	B. cereus and S. aureus	[186]
Pomegranate peel extract	To maintain the quality of mackerel fillets wrapped with gelatin/polycaprolactone composite film and to prolong the shelf life of the product	Total mesophilic counts and psychrotrophic bacteria counts	[187]