Table 4.
Antimicrobial activity of combinations of lysozyme with antibiotics against Gram-negative and Gram-positive bacteria.
| Minimal FICIs a of the Lysozyme\Antibiotic Combination (AB) against Bacteria | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Gram-Negative | Gram-Positive | ||||||||||
| AB | RIF | PMB | GEN | OFL | OX | AB | RIF | PMB | GEN | OFL | OX |
| E. coli ML-35p | MRSA ATCC 33591 | ||||||||||
| Lysozyme | 0.62 | 0.25 | 0.53 | 1.12 | - | Lysozyme | 0.62 | 0.56 | 0.53 | 1.12 | 0.53 |
| A. baumannii | M. luteus CIP A270 | ||||||||||
| Lysozyme | 1 | 0.5 | 0.75 | 1 | 1 | Lysozyme | 0.75 | 0.62 | 0.62 | 0.62 | 0.75 |
RIF, rifampicin; PMB, polymyxin B; GEN, gentamicin; OFL, ofloxacin; and OX, oxacillin. a Fractional inhibitory concentration indices (FICI) = [A]/[MIC A] + [B]/[MIC B], where [A] and [B] are the respective concentrations of substances A and B in their combination, effectively inhibiting bacterial growth; FICI > 2 indicates antagonism, 1 < FICI ≤ 2 shows independent action, 0.5 < FICI ≤ 1 corresponds to additivity, and FICI ≤ 0.5 denotes synergy.