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. 2021 Dec 1;11(12):1805. doi: 10.3390/biom11121805

Figure 7.

Figure 7

Chemical space visualization of the virtual focused compound library of HIV-1 viral protease inhibitors from natural product fragments and two compound reference libraries using TMAP based on molecular fingerprints. Compounds reference libraries represented in colors: FDA-approved drugs (blue), and FDA-approved HIV-1 protease inhibitors (purple). Likewise, for new chemical compounds generated from COCONUT (orange), ChemDiv (red), and Enamine (green) fragment libraries. The interactive version is available at https://figshare.com/s/ceb58d58e8f5585ce67e (accessed on 5 November 2021).