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. 2021 Nov 29;9(12):1789. doi: 10.3390/biomedicines9121789

Figure 4.

Figure 4

VEGFR2 protein expression is modulated through gene regulation by FAK in TNBC cells. (A) Knockdown of FAK decreased protein expressions of VEGFR2, p-FAK, and VEGF but knockdown of VEGFR2 did not affect these protein expressions in MDA-MB-231 and MDA-468 cells. (B) Protein expressions of VEGFR2, p-FAK, and VEGF were reduced in two stable clones of knockdown FAK MDA-Mb-231 cells. (C) VEGFR2 protein expressions in MDA-MB-231 and MDA-MB-468 cells were significant suppressed through PF-562271 treatment. (D) Overexpression of FAK could also increase VEGFR2, p-FAK, and VEGF protein expression in MDA-MB-231 and MDA-MB-468 cells.