Table 1.
An overview of the use of BXD RI strain in studies of the neurotoxicity in response to ethanol, cocaine, metals and pesticide exposures.
| Substance | Dose | Mainly Finds | Reference |
|---|---|---|---|
| Ethanol | Inhalation of ethanol vapor for 3 days | Influence of gene on ethanol withdrawal severity | [26] |
| Ethanol | 4 g/kg | A cluster of genes (Scn1, Scn2, Scn3) code for voltage-sensitive sodium channel proteins, genes candidates for affecting withdrawal ethanol | [27] |
| Ethanol | 4 g/kg | 800 mapped polymorphic genetic markers were associated with sensitivity and/or tolerance to ethanol | [28] |
| Ethanol | 2 g/kg | QTL analyses identified significant marker associations with basal activity, acute locomotor response on chromosomes 3, 4, 7, 11, 12, 13, 15, 17 | [31] |
| Ethanol | 2 g/kg | Association between ethanol-seeking behavior and genetic markers on chromosomes 4, 8, 9, 18 and 19 | [32] |
| Ethanol | 1.5 g/kg | Association between ethanol and locomotor activity on chromosomes 1, 2, 4, and 6 | [33] |
| Ethanol | 2.25 g/kg | Ethanol-induced locomotor activation on chromosomes 2 and 5 | [34] |
| Ethanol | 4.1 g/kg | QTL analyses correlating strain means with allelic status at >1500 markers | [36] |
| Ethanol | 4 g/kg | Ethanol withdrawal is associated with c-Fos expression in the basal ganglia and associated circuitry | [39] |
| Ethanol | 2 g/kg | 45 ethanol-related phenotypes were significantly correlated with Coq7 expression | [41] |
| Cocaine | 60 mg/kg | QTL association on chromosomes 6 and 12 with susceptibility to cocaine-induced seizures | [50] |
| Cocaine | a | TLs associated with the susceptibility to cocaine-induced seizures on chromosomes 9 (proximal) and 15 (distal) and on chromosome 9 were sex-specific | [51] |
| Cocaine | b | Genes on proximal chromosome 19 were correlated with DAT expression levels | [54] |
| Cocaine | 5, 10 and 40 mg/kg | QTLs for locomotion on chromosomes 1, 3–6, 9, 12, 13, 18, and 19 were associated with cocaine response | [55] |
| Iron | 240 ppm | Glutamate transporter 1 (GLT1) gene on chromosome 2 as a key regulator gene of iron homeostasis | [63] |
| Iron | 240 ppm | Identified 11 regions with nucleotide polymorphism on chromosomes 1, 2, 5, 7, 9. 11, 13, 14, 17, and 18 in the ventral midbrain | [72] |
| Iron | 240 ppm | BXD 19 and 31 strains had higher up-regulation of Hbb-b1 | [75] |
| Copper | 13 ppm | Association between copper regulation and QTL analyses on chromosome 16 in the caudate-putamen (CP) of males, QTL on chromosome 12 in the CP and nucleus accumbens (NA) in females and on chromosomes 3, 13, and 17 in the prefrontal cortex (PFC) of males | [18] |
| Copper | b | QTL in chromosomes 14 and 9 associated with copper homeostasis | [59] |
| Zinc | 70 ppm | Zn concentration was correlated in QTL region on chromosome 8 in the NA of females and on chromosomes 3, 13, and 17 in males in PFC | [18] |
| Zinc | b | QTL on chromosome 9 was correlated with zinc content in the hippocampus | [59] |
| Diisopropyl fluorophosphate | 4 mg/kg | 21 differentially expressed genes having significant QTLs related to CORT + DFP | [3] |
| Paraoxon | 0–1 mg/kg | Paraoxon treatment reduced locomotor activity and this depression was dependent on the genotype | [96] |
a: Doses needed to induce a running, bouncing clonic seizure and a tonic hindlimb extensor seizure were recorded for each mouse. b: not informed.