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Effects of diosmin pretreatment on light micrographs of the H & E stain liver tissues of 0.1 mm. (A) The normal tissue of the liver. (B) Irregular architecture of liver tissues caused by Dox administration appeared, as indicated by arrows. (C,D) Diosmin pre-treatment reduced harmful effects of Dox in cytoplasmic vacuoles, necrotic hepatocytes, and vascular congestion at both doses.
