TABLE 1.

Q-FISH and cytogenetic analysis of wild-type and DNA-PKcs^−/− MEFs

Litter	Genotype	Chr.a arm	Telomere length (kb) (SD, SE)	No. of chr. aberrations			No. of metaphases
				Telomere fusionsb	Chr. breaks or fragmentsc	Telomere associationsd
A1	−/−	p	28.24 (9.78, 0.2)	6	4	7	100
		q	33.66 (11.38, 0.23
		Avg	30.95 (10.58, 0.219)
A2	+/−	p	29.5 (9.41, 0.19)	6	2	14	100
		q	34.92 (10.6, 0.021)
		Avg	32.21 (10.01, 0.2)
B6	−/−	p	31.65 (10.73, 0.219)	7	2	21	100
		q	36.5 (10.24, 0.209)
		Avg	34.08 (10.48, 0.21)
B5	WTe	p	32.61 (11.17, 0.22)	2	2	13	100
		q	37.7 (10.03, 0.2)
		Avg	35.15 (10.6, 0.21)
C2	−/−	p	34.56 (9.49, 0.19)	6	4	19	100
		q	40.27 (11.13, 0.22)
		Avg	37.42 (10.31, 0.21)
C5	WT	p	30.81 (8.61, 0.17)	1	4	10	80
		q	38.97 (9.94, 0.2)
		Avg	34.89 (9.28, 0.19)
C3	WT	p	31.58 (10.54, 0.21)	2	3	10	100
		q	38.45 (11.8, 0.24)
		Avg	35.01 (11.17, 0.22)
C9	−/−	p	27.78 (8.22, 0.16)	6	0	11	80
		q	32.92 (9.96, 0.2)
		Avg	30.35 (9.09, 0.18)

^aChr., chromosome. 

^bAverage numbers per metaphase: wild type, 0.017; DNA-PKcs^−/−, 0.065. 

^cAverage numbers per metaphase: wild type, 0.032; DNA-PKcs^−/−, 0.026. 

^dAverage numbers per metaphase: wild type, 0.012; DNA-PKcs^−/−, 0.015. 

^eWT, wild type.