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. 2021 Dec 6;9(12):1846. doi: 10.3390/biomedicines9121846

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The sensitivity of leukemia and NB cells to belinostat (BEL) and hydrazostat (HYD). (a) Viability of leukemia (HL-60, Kasumi-1, and K562) and NB (LAN-1, SK-N-AS, and Kelly) cells treated with belinostat (green) and hydrazostat (pink) relative to DMSO treated cells. (b) IC50 values of belinostat (green) and hydrazostat (pink) of leukemia (circle) and NB (triangle) cell lines with comparable sensitivity of belinostat and hydrazostat (left) and increased sensitivity to hydrazostat (right). All experiments were performed in three replicates. Cells were counted by trypan blue exclusion on day 3 after the addition of inhibitors. p-value was determined by Mann–Whitney test.