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. 2021 Dec 6;9(12):1846. doi: 10.3390/biomedicines9121846

Figure 2.

Figure 2

Correlation of HDACs genes expression with all human receptor tyrosine kinases. (a) Elastic net coefficients of HDAC class I and II with RTK-coding genes in AML (N = 525) and NB (N = 88) patients. The color indicates the value of the correlation coefficient determined by the elastic regression method. Genes are ranged by the SCORE that is determined as the sum of squared coefficients for HDAC1, 2, 3, 6,8, SCORE I is determines as the sum of squared coefficients for HDAC1, 2, 3, 8. Top 15 genes according to the SCORE are shown. (b) Correlation coefficients of HDAC class I and II with RTK-coding genes in leukemia and NB cell lines. The color indicates the value of the correlation coefficient determined by the elastic net regression model. Genes are ranged by the SCORE that is determined as the sum of squared coefficients for HDAC 1, 2, 3, 6, 8, SCORE I is determined as the sum of squared coefficients for HDAC 1, 2, 3, 8. Top 15 genes according to the SCORE are shown. (c) Average expression of gene vs. its SCORE in cell lines. Average expression was determined for 59 leukemia and 29 neuroblastoma cell lines. NB are presented as green circles, and leukemia as purple triangles.