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. 2021 Dec 8;10(12):1296. doi: 10.3390/biology10121296

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Holistic bioinformatics analysis of previously established glaucoma-related autoantigens. (A) Protein–protein interaction network. Twenty-two of the twenty-eight glaucoma-related antigens have at least one interaction partner among each other. Especially strong interactions were observed for six antigens (HSPA1A, HSPD1, YWHAZ, VDAC2, PGAM1, ENO2), that were identified by the Metaspcape algorithm MCODE (marked with red spots). (B) GO analysis of 28 glaucoma-related antigens. Shown are significantly enriched GO terms of biological processes and reactome gene sets. (C) GO analysis of MCODE cluster antigens only. Published in Beutgen et al. 2021 [117]. This work is open access. The copyright is available online: http://creativecommons.org/licenses/by/4.0/ (accessed on 7 December 2021).