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Summary of thioridazine’s anti-tumor mechanism of action. Key: VEGF, Vascular endothelial growth factor; PI3/AKT, phosphoinositide-3-kinase–protein kinase B/Akt HIF-1a, Hypoxia-inducible factor-1a; WNT, Wingless and Int-1; mTOR, Mammalian target of rapamycin; CDK2, Cyclin-dependent kinase 2; FAK, Focal adhesion kinase; ROS, Reactive oxygen species.
