Table 3.
The synergistic activity of azithromycin in combination with other antibiotics against OXA-48-producing K. pneumoniae isolates.
| Isolate | OMP | MIC (Mg/L) (Interpretation) | Antibiotic Resistance Gene | FICI (Interpretation) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ompk35 | Ompk36 | IPM | CT | FOF | AZM | fosa3 | fosa5 | ermB | ermC | AZM + IPM |
AZM + CT |
AZM + FOF |
|
| KP162 | − | − | 16 (R) | 0.5 (S) | 128 (R) | 64 (R) | − | + | − | + | 0.75 (N) | 0.5 (Syn) | 0.38 (Syn) |
| KP197 | − | + | 8 (R) | 0.5 (S) | 32 (S) | 32 (R) | + | + | − | + | 2 (N) | 0.5 (Syn) | 0.5 (Syn) |
| KP203 | + | + | 0.5 (S) | 0.5 (S) | 16 (S) | 8 (S) | − | + | − | + | 2 (N) | 0.5 (Syn) | 0.38 (Syn) |
| KP166 | − | − | 32 (R) | 0.25 (S) | 256 (R) | 32 (R) | + | + | − | + | 0.75 (N) | 0.5 (Syn) | 0.38 (Syn) |
| KP260 | − | − | 32 (R) | 0.5 (S) | 256 (R) | 1024 (R) | − | + | + | + | 2 (N) | 0.38 (Syn) | 0.75 (N) |
| KP262 | − | − | 128 (R) | 0.25 (S) | 256 (R) | 1024 (R) | + | + | + | + | 0.75 (N) | 0.75 (N) | 0.75 (N) |
| KP1184 | − | + | 64 (R) | 1 (S) | 512 (R) | 16 (S) | + | + | − | + | 0.5 (Syn) | 0.38 (Syn) | 0.38 (Syn) |
| KP221 | + | + | 0.5 (S) | 0.5 (S) | 8 (S) | 128 (R) | − | + | − | + | 0.75 (N) | 0.38 (Syn) | 0.38 (Syn) |
| KP241 | − | − | 128 (R) | 0.25 (S) | 128 (R) | 128 (R) | + | + | − | + | 0.75 (N) | 0.5 (Syn) | 0.38 (Syn) |
FICI: Fractional Inhibitory Concentration Index; IPM: Imipenem; CT: Colistin; FOF: Fosfomycin; AZM: Azithromycin; −: Absence; +: Presence; R: Resistant; S: Susceptible; Syn: Synergism; N: No interaction.