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. 2021 Dec 18;9(12):1944. doi: 10.3390/biomedicines9121944

Table 2.

Top 15 plasma metabolites that significantly differ between patients with amyotrophic lateral sclerosis (ALS) and age- and sex-matched normal controls (NCs).

Compound Name NC (n =36) ALS (n =36) p Value
ADMA (μM) 0.45 ± 0.10 0.59 ± 0.11 p < 0.001
Creatinine (μM) 75.81 ± 16.78 51.16 ± 20.91 p < 0.001
PC ae C34:3 (μM) 5.88 ± 1.19 4.31 ± 1.41 p < 0.001
PC ae C38:2 (μM) 1.43 ± 0.68 0.81 ± 0.41 p < 0.001
PC ae C30:2 (μM) 0.06 ± 0.01 0.05 ± 0.01 p < 0.001
Tyrosine (μM) 75.29 ± 15.68 59.58 ± 13.91 p < 0.001
PC ae C34:2 (μM) 8.13 ± 1.65 6.57 ± 1.41 p < 0.001
Tryptophan (μM) 65.06 ± 14.17 52.35 ± 10.85 p < 0.001
Methionine (μM) 28.38 ± 5.57 23.16 ± 5.03 p = 0.001
Phenylalanine (μM) 71.29 ± 9.95 61.02 ± 11.23 p = 0.001
PC aa C42:2 (μM) 0.34 ± 0.07 0.27 ± 0.07 p = 0.001
PC ae C30:0 (μM) 0.20 ± 0.06 0.15 ± 0.04 p = 0.001
PC aa C40:2 (μM) 0.41 ± 0.13 0.31 ± 0.08 p = 0.002
PC aa C34:2 (μM) 171.00 ± 20.29 190.19 ± 21.92 p = 0.002
lysoPC a C26:1 (μM) 0.05 ± 0.02 0.04 ± 0.01 p = 0.002

p value: analysis of covariance (ANCOVA) adjustment for body mass index, with false discovery rate correction. aa: acyl-acyl; ae: acyl-alkyl; ADMA: asymmetric dimethylarginine; OH: hydroxy; lysoPC: lysophosphatidylcholine; PC: phosphatidylcholine; SM: sphingomyelin.