Figure 4.

Crystal structures of inhibitors 1 and 2 in complex with wild type ALR-2. Inhibitors 1 (4YS1) [4] in light green (A,B) and 2 (4QBX) [4] in dark green (C,D) bound to the active site of ALR-2. To distinguish the position of both conformations, b is highlighted by a slightly darker color. On the left, the protein is depicted by its transparent solvent-accessible surface (light grey), whereas on the right, the interactions are indicated as black lines. Selected residues are displayed for better orientation.