Table 1.
Clinical and demographic characteristics of CML patients at diagnosis.
| Clinical/Demographic Features | Pediatric (n = 9) |
Adult (n = 10) |
Pediatric vs. Adult | ||
|---|---|---|---|---|---|
| n | % | n | % | p-value * | |
| Demographic characteristics | |||||
| Age at diagnosis (years) | |||||
| Median (IQR) | 10 (9–13) | 54 (33–62) | <0.0001 | ||
| Sex | |||||
| Male | 8 | 88.9 | 9 | 90.0 | 1.0000 |
| Female | 1 | 11.1 | 1 | 10.0 | |
| Race/Ethnicity | |||||
| Asian | 4 | 44.4 | 1 | 10.0 | 0.1771 |
| Hispanic | 2 | 22.2 | 2 | 20.0 | |
| White non-Hispanic | 2 | 22.2 | 6 | 60.0 | |
| Black non-Hispanic | 0 | 0 | 1 | 10.0 | |
| Other | 1 | 11.1 | 0 | 0 | |
| Clinical features at diagnosis | |||||
| CML diagnosis | |||||
| Chronic phase | 7 | 77.8 | 10 | 100.0 | 0.2105 |
| Unknown/not reported | 2 | 22.2 | 0 | 0 | |
| WBC count (×109/liter) $ | |||||
| Median (IQR) | 255 (95–351) | 143 (64–260) | 0.4908 | ||
| Platelet count (×109/liter) $ | |||||
| Median (IQR) | 627 (617–870) | 305 (205–371) | 0.0004 | ||
| Spleen size (cm) + | |||||
| Median (IQR) | 5 (2–5) | 0 (0–0) | 0.0739 | ||
Abbreviations: IQR, interquartile range; WBC, white blood cell; * p-values from Fisher’s exact test (categorical variables) or Wilcoxon rank sum test (continuous variables); $ based on n = 7 pediatric patients (all chronic phase) and n = 10 adult patients with data available; + spleen size calculated as centimeters (cm) below the costal margin at diagnosis; based on n = 5 pediatric patients (all chronic phase) and n = 10 adult patients with data available.