Table 1.

Select XPO1 cargos implicated in childhood cancer pathogenesis.

Cargo	Normal Function	Result of XPO1 Inhibition	Citation
IkB	NF-kB transcription factor signaling	Inhibition of cell survival-promoting NF-kB transcription factor activity	[30]
Survivin (BIRC5)	Inhibition of apoptosis	Degraded to release inhibition of apoptotic pathway	[31]
CDKN1A (p21)	Cell cycle kinase	Halts cell cycle progression, leading to cell cycle arrest	[32]
CDKN1B (p27)	Cell cycle inhibitor	Halts cell cycle progression, leading to cell cycle arrest	[33]
p53	DNA damage recognition	TP53-dependent apoptosis proceeds	[34]
pRB	Cell cycle regulator	Halts cell cycle progression, leading to cell cycle arrest	[35]
FOXO1	Transcription factor-Differentiation	Promotes sensitivity to selinexor in cisplatin-based combination	[36]
pMAPK	MAPK/Developmental signaling processes	Promotes apoptosis by decreasing pro-survival ERK pathways	[37]
APC	β-catenin signaling	Reduction of β-catenin levels by binding and leading to destruction; halts stemness-inducing Wnt signaling	[38,39]