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. 2021 Nov 24;10(12):3282. doi: 10.3390/cells10123282

Figure 6.

Figure 6

Mitochondria from skeletal muscle, cardiac muscle, and renal tissue express unique mitochondrial proteome alterations in CKD. (A) Experimental approach for TMT-labeled proteomic assessments; (B) Protein abundance analysis of skeletal muscle, cardiac muscle and renal tissue mitochondria volcano plots using. Dashed lines indicate the unadjusted -log10 p = 0.05 demonstrating differentially expressed proteins in CKD mice; (C) Venn diagram comparisons of all significantly expressed proteins (adjusted p < 0.05), all downregulated proteins, and all upregulated proteins in all three tissues of control and CKD mice; (D) Gene ontology analysis of differentially expressed proteins in skeletal muscle, cardiac muscle, and renal tissue isolated mitochondria in control and CKD mice (n = 3/group/tissue).