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. 2021 Dec 20;13(24):6389. doi: 10.3390/cancers13246389

Figure 1.

Figure 1

Decreased bile flow and alterations in the hepatobiliary transport system in C26 cachectic mice. (a) Bile flow in sham-injected mice (CT; n = 4) and colon carcinoma 26-transplanted mice (C26; n = 8). (b) Hepatic mRNA expression levels of genes involved in the hepatobiliary transport system in CT and C26 mice. Ntcp, Na(+)/taurocholate transport protein; Oatp1β2, organic anion transporter family member 1B2; Bsep, bile salt export pump; Mrp2, multidrug resistance-associated protein 2; Ostβ, organic solute transporter subunit beta. n = 4–8 mice per group; data are presented as mean ± SEM, * p < 0.05, ** p < 0.01, *** p < 0.001.