Skip to main content
. 2021 Dec 20;13(24):6389. doi: 10.3390/cancers13246389

Figure 6.

Figure 6

UDCA treatment worsens muscle atrophy in C26 cachectic mice. (a) Tibialis weight in sham-injected mice (CT), sham-injected mice treated with UDCA (CT-UDCA), mice injected with cachexia-inducing C26 colon carcinoma cells (C26), and mice injected with cachexia-inducing C26 colon carcinoma cells and treated with UDCA (C26-UDCA). Tibialis mRNA expression levels of genes involved in the ubiquitin-proteasome pathway (b), autophagy-lysosome pathway (c), differentiation (d), and mitochondrial function (e). Trim63, tripartite motif-containing 63 (also known as Murf1); Fbxo32, F-box protein 32 (also known as Atrogin1); Musa1, muscle ubiquitin ligase of the SCF complex in atrophy 1; Map1lc3a, microtubule-associated protein 1 light chain 3 alpha; Ctsl, cathepsin L; Igf1, insulin-like growth factor 1; Myog, myogenin; MyoD, myogenic differentiation 1; Pax7, paired box 7; Ucp2, uncoupling protein 2; Ppargc1a, PPARG coactivator 1 alpha. n = 7–8 mice per group; data are presented as mean ± SEM. # p < 0.05 ## p < 0.01 C26 vs. C26-UDCA.