Figure 3.

Common variant GWAS of liver fat in 32,974 individuals identifies eight loci

Associations of 9.8 million common (alternate allele frequency > 1%) genetic variants with inverse normal transformed liver fat, quantified from MRI data using machine learning, in 32,974 individuals from the UK Biobank were assessed using linear mixed models. Results of each variant association are shown with chromosome and base pair position of the variant on the x axis and −log₁₀(p value) of the association with liver fat on the y axis. The lead variants at each of 8 genome-wide significant loci are indicated by orange points. A gray line indicates the genome-wide significance threshold (p = 5 × 10⁻⁸). See also Figure S4.