Figure 2.

ITGA2 methylation can predict survival in the TCGA pancreatic cancer cohort. (a) Probe location within the gene is shown (scheme is at scale). (b) Kaplan–Meier curve for OS (log-rank test). The cut-off value for cg08446038 methylation was 0.2796 with sensitivity and specificity of 58.58% and 87.50%, respectively. Patients with methylation levels inferior and superior to the cut-off were considered as lowly (represented in blue) and highly methylated (represented in red), respectively. (c) Comparison of methylation levels between normal and tumour tissue (mean ± SD; Mann–Whitney test). HR, hazard ratio.