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. 2021 Dec 17;13(24):6354. doi: 10.3390/cancers13246354

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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PIK3R1 methylation can predict survival in the TCGA pancreatic cancer cohort. (a) Probe location within the gene is shown (scheme is at scale). (b) Kaplan–Meier curve for OS (log-rank test). The cut-off value for cg15021292 was 0.6473, with sensitivity and specificity values of 75.60% and 87.50%, respectively. Patients with methylation levels inferior and superior to the cut-off were considered as lowly and highly methylated, respectively. (c) Comparison of methylation levels between normal and tumour tissue (mean ± SD; Mann–Whitney test). HR, hazard ratio.